Neuromuscular blocking properties of some antibiotics in man.

  title={Neuromuscular blocking properties of some antibiotics in man.},
  author={Y. Hashimoto and T. Shima and S. Matsukawa and K. Iwatsuki},
  journal={The Tohoku journal of experimental medicine},
  volume={117 4},
Neuromuscular blocking properties of ribostamycin (1 gm), dibecacin (100 mg) and tobramycin (60 mg) were studied in a man during anesthesia and surgery by observing the effects of these antibiotics on muscle twitch tension. These drugs alone did not show any neuromuscular blocking action in those therapeutic doses. However, during the recovery phase of d-tubocurarine block the intravenous administration of 1 gm of ribostamycin caused a fairly rapid decrease in twitch tension. Tobramycin 60 mg… Expand
2 Citations
Neuromuscular blocking property of amikacin in man.
Data obtained from the peroneal nerve-anterior tibial muscle preparation of rabbits suggested that the neuromuscular blocking potency of amikacin was one-twelfth of that of kanamycin in therapeutic doses, which means that caution should be taken in its use for patients with myasthenic state. Expand
Effects of aminoglycoside antibiotics on cholinergic autonomic nervous transmission.
The results suggest that the site for the block of aminoglycosides is mainly the cholinergic nerve terminal, where they reduce the available Ca ions required for the release of ACh. Expand