Neuromuscular blocking characteristics of vecuronium after tubocurarine-induced “fade”An experimental double-blind clinical study

  title={Neuromuscular blocking characteristics of vecuronium after tubocurarine-induced “fade”An experimental double-blind clinical study},
  author={A. Puura and G. Baer and M. Rorarius},
  journal={European Journal of Clinical Pharmacology},
AbstractObjective: The fade in train-of-four (TOF) monitoring is considered to be due to blocking of the prejunctional nicotinic acetylcholine receptors (AchRs). During onset of the neuromuscular block (NMB) tubocurarine (TC) causes more fade in the TOF responses than vecuronium (VEC). Therefore we wanted to investigate whether onset or duration of action of VEC or TC would be improved with a priming dose of an agent with different prejunctional activity. Methods: The rates of NMB were… Expand
1 Citations


Onset of pancuronium and d-tubocurarine blockade with priming
It is concluded that priming with a synergistic relaxant might increase speed of onset without prolonging the duration of neuromuscular blockade. Expand
Onset of Maximum Neuromuscular Block Following Succinylcholine or Vecuronium in Four Age Groups
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Refining the priming principle for vecuronium during rapid-sequence induction of anesthesia.
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Refining the Priming Principle for Vecuronium during Rapid‐sequence Induction of Anesthesia
The authors conclude that when vecuronium is used for rapid establishment of neuromuscular blockade during induction of anesthesia, 0.01 mg/ kg iv should be given 4 min prior to 0.1 mg/kg iv. Expand
Vecuronium and d‐Tubocurarine Combination: Potentiation of Effect
C cumulative dose-response curves were constructed and showed the combination of vecuronium plus d-tubocurarine to be significantly more potent than would be expected from a simple additive effect of the individual drugs given alone. Expand
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The combination of pancuronium and d-tubocurarine is associated with potentiation of the neuromuscular blocking effects of each drug used singly and was associated with greater cardiovascular stability. Expand
Is the Priming Principle Both Effective and Safe?
It is concluded that priming shortens the onset of NMB similarly between V, P and A but the priming dose producing the most rapid onset ofNMB also results in a high incidence of side effects and therefore thePriming principle should be used with caution. Expand
Role of Histamine in the Hypotensive Action of d‐Tubocurarine in Humans
A sensitive radioenzymatic assay for plasma histamine and data suggest that histamine release is an important factor in the hypotension accompanying dTc administration in humans. Expand
Vecuronium induced neuromuscular blockade
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Effects of Neuromuscular Blocking Agents on Neuronal Nicotine Receptors of Motor Nerves: Blockade of Nicotinic Autofacilitation and Backfiring
ABSTRACT Tubocurarine reduced (60%) [3H]acetylcholine release from the isolated rat phrenic nerve at concentrations of 1 or 10 μM, but blocked backfiring of the phrenic nerve occuring after partialExpand