Neuromodulatory control of striatal plasticity and behavior.

  title={Neuromodulatory control of striatal plasticity and behavior.},
  author={Talia N. Lerner and Anatol Kreitzer},
  journal={Current opinion in neurobiology},
  volume={21 2},
Excitatory synapses onto projection neurons in the striatum, the input nucleus of the basal ganglia, play a key role in regulating basal ganglia circuit function and are a major site of long-term synaptic plasticity. Here, we review the mechanisms and regulation of both long-term potentiation and long-term depression at these synapses. In particular, we highlight the role that neuromodulators play in determining the strength and direction of plasticity, which ultimately shapes the balance of… CONTINUE READING