Neuromodulators Control the Polarity of Spike-Timing-Dependent Synaptic Plasticity

  title={Neuromodulators Control the Polarity of Spike-Timing-Dependent Synaptic Plasticity},
  author={Geun Hee Seol and Jokubas Ziburkus and Shiyong Huang and Lihua Song and In Tae Kim and Kogo Takamiya and Richard L. Huganir and Hey-Kyoung Lee and Alfredo Kirkwood},
Near coincidental pre- and postsynaptic action potentials induce associative long-term potentiation (LTP) or long-term depression (LTD), depending on the order of their timing. Here, we show that in visual cortex the rules of this spike-timing-dependent plasticity are not rigid, but shaped by neuromodulator receptors coupled to adenylyl cyclase (AC) and phospholipase C (PLC) signaling cascades. Activation of the AC and PLC cascades results in phosphorylation of postsynaptic glutamate receptors… CONTINUE READING
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