Neuromodulation of enteropathogen internalization in Peyer's patches from porcine jejunum

  title={Neuromodulation of enteropathogen internalization in Peyer's patches from porcine jejunum},
  author={Benedict T. Green and Mark Lyte and Anjali Kulkarni-Narla and David R Brown},
  journal={Journal of Neuroimmunology},
Jejunal Peyer's patches (JPP) are innervated sites of immune induction and enteropathogen infection. We investigated the role of enteric nerves in modulating pathogen entry into porcine JPP. Presumptive norepinephrine (NE)-containing nerve fibers were localized in JPP domes and follicle-associated villi by secondary immunofluorescence histochemistry. NE or the neuronal conduction blocker saxitoxin increased intracellular internalization of pathogenic Salmonella choleraesuis and Escherichia coli… CONTINUE READING


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