Neuromodulation of Neuronal Circuits: Back to the Future

@article{Marder2012NeuromodulationON,
  title={Neuromodulation of Neuronal Circuits: Back to the Future},
  author={E. Marder},
  journal={Neuron},
  year={2012},
  volume={76},
  pages={1-11}
}
  • E. Marder
  • Published 2012
  • Medicine, Biology
  • Neuron
All nervous systems are subject to neuromodulation. Neuromodulators can be delivered as local hormones, as cotransmitters in projection neurons, and through the general circulation. Because neuromodulators can transform the intrinsic firing properties of circuit neurons and alter effective synaptic strength, neuromodulatory substances reconfigure neuronal circuits, often massively altering their output. Thus, the anatomical connectome provides a minimal structure and the neuromodulatory… Expand
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