Neuromodulation of Na+ channels: An unexpected form of cellular platicity

  title={Neuromodulation of Na+ channels: An unexpected form of cellular platicity},
  author={A. R. Cantrell and W. Catterall},
  journal={Nature Reviews Neuroscience},
  • A. R. Cantrell, W. Catterall
  • Published 2001
  • Medicine, Biology
  • Nature Reviews Neuroscience
  • Voltage-gated Na+ channels set the threshold for action potential generation and are therefore good candidates to mediate forms of plasticity that affect the entire neuronal output. Although early studies led to the idea that Na+ channels were not subject to modulation, we now know that Na+ channel function is affected by phosphorylation. Furthermore, Na+ channel modulation is implicated in the control of input–output relationships in several types of neuron and seems to be involved in… CONTINUE READING
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