Neuromodulation and cortical function: modeling the physiological basis of behavior

  title={Neuromodulation and cortical function: modeling the physiological basis of behavior},
  author={Michael E. Hasselmo},
  journal={Behavioural Brain Research},
  • M. Hasselmo
  • Published 1 February 1995
  • Biology, Psychology
  • Behavioural Brain Research

Figures from this paper

Dopaminergic Regulation of Neuronal Circuits in Prefrontal Cortex

Neuromodulators, like dopamine, have considerable influence on the processing capabilities of neural networks. This has for instance been shown in the working memory functions of prefrontal

Function of Selective Neuromodulatory Projections in the Mammalian Cerebral Cortex: Comparison Between Cholinergic and Noradrenergic Systems

The basal forebrain cholinergic projection and the locus coeruleus noradrenergic projection are well-known neuromodulatory projections to the cortex and their roles in controlling four major brain functions: attention, reinforcement, learning and memory, sleep and wakefulness are highlighted.

Noradrenergic suppression of synaptic transmission may influence cortical signal-to-noise ratio.

In a computational model of the piriform cortex, the effect of noradrenergic suppression of synaptic transmission on signal-to-noise ratio is analyzed and increases in levels of norepinephrine mediated by locus coeruleus activity appear to enhance the influence of extrinsic input on cortical representations.

Cholinergic modulation of cortical function

The physiological effects of acetylcholine serve to enhance the influence of feed- forward afferent input to the cortex while decreasing background activity by suppressing excited feedback connections within cortical circuits.

Noradrenergic Regulation of Hippocampus-Dependent Memory.

Advances in the understanding of noradrenaline in the context of these processes may provide a foundation for refining treatment strategies for multiple brain diseases, ranging from post-traumatic stress disorder to Alzheimer's Disease.

Contribution of acetylcholine to visual cortex plasticity

  • Q. Gu
  • Biology
    Neurobiology of Learning and Memory
  • 2003

Network architecture, receptive fields, and neuromodulation: computational and functional implications of cholinergic modulation in primary auditory cortex.

This work developed a computational model of layers III and IV of AI, constrained by anatomical and physiological data, and identifies key thalamocortical and intracortical circuits that strongly affect tuning curves of model cortical neurons and are also sensitive to cholinergic modulation.

Differences in time course of ACh and GABA modulation of excitatory synaptic potentials in slices of rat hippocampus.

In brain slice preparations of hippocampal region CA1, the time course of suppression of extracellularly recorded synaptic potentials after pressure pulse application of acetylcholine and GABA is explored, to give a notion of the relative timecourse of the two modulators.

Sensory-motor gating and cognitive control by the brainstem cholinergic system

Data-driven modeling of cholinergic modulation of neural microcircuits: bridging neurons, synapses, and network states

A data-driven framework incorporating phenomenological models of the anatomy and physiology of cholinergic modulation of the neocortex is developed, which corroborate the long-standing notion that ACh desynchronizes network activity, and reveals a potentially finegrained control over a spectrum of neocortical states.



Acetylcholine and Learning in a Cortical Associative Memory

It is proposed that the effects of acetylcholine in cortical structures may provide a neuropsychological mechanism for clamping activity to the patterns to be learned, which prevents interference from previously stored patterns during the learning of new patterns.

Modulation of associative memory function in a biophysical simulation of rat piriform cortex.

A realistic biophysical simulation of the effects of acetylcholine on synaptic transmission and neuronal adaptation in the piriform cortex shows that these effects act together to set the appropriate dynamics for learning, whereas removal of both effects sets theappropriate dynamics for recall.

Modulation of Neuronal Adaptation and Cortical Associative Memory Function.

The adaptation of cortical pyramidal cells was tested during intracellular recording from brain slice preparations and the properties of this adaptation were simulated with voltage and calcium

Noradrenaline blocks accommodation of pyramidal cell discharge in the hippocampus

It is found that NA and cyclic AMP block the Ca2-activated K+ conductance in hippocampal pyramidal cells and that this blockade occurs at a step subsequent to the entry of Ca2+ into the neurone, which greatly increases the number of spikes elicited by a depolarizing stimulus.

Laminar selectivity of the cholinergic suppression of synaptic transmission in rat hippocampal region CA1: computational modeling and brain slice physiology

  • ME HasselmoE. Schnell
  • Biology
    The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 1994
Data support the hypothesis that synaptic modification of the Schaffer collaterals may store associations between activity in region CA3 and the afferent input to region CA1 from the entorhinal cortex.

Presynaptic inhibitory effect of acetylcholine in the hippocampus

It is concluded that ACh exerts a presynaptic inhibitory effect on both excitatory and inhibitory afferents to hippocampal pyramidal neurons, occurring in all regions of Ammon's horn tested as well as in stratum moleculare of fascia dentata.

Cholinergic modulation of cortical associative memory function.

A possible theoretical framework for linking the neuropharmacological effects of acetylcholine to behavioral evidence for a role of acetolcholine in memory function is provided, which could help describe how memory deficits might arise from cholinergic dysfunction in diseases such as Alzheimer's dementia.