Neuromodulation: acetylcholine and memory consolidation

  title={Neuromodulation: acetylcholine and memory consolidation},
  author={M. Hasselmo},
  journal={Trends in Cognitive Sciences},
  • M. Hasselmo
  • Published 1999
  • Medicine, Psychology
  • Trends in Cognitive Sciences
  • Clinical and experimental evidence suggests that hippocampal damage causes more severe disruption of episodic memories if those memories were encoded in the recent rather than the more distant past. This decrease in sensitivity to damage over time might reflect the formation of multiple traces within the hippocampus itself, or the formation of additional associative links in entorhinal and association cortices. Physiological evidence also supports a two-stage model of the encoding process in… CONTINUE READING

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