Neuromelanin of the Human Substantia Nigra: An Update

@article{Zucca2013NeuromelaninOT,
  title={Neuromelanin of the Human Substantia Nigra: An Update},
  author={F. Zucca and E. Basso and F. Cupaioli and E. Ferrari and D. Sulzer and L. Casella and L. Zecca},
  journal={Neurotoxicity Research},
  year={2013},
  volume={25},
  pages={13-23}
}
Dopaminergic neurons of the substantia nigra selectively degenerate over the course of Parkinson’s disease. These neurons are also the most heavily pigmented cells of the brain, accumulating the dark pigment neuromelanin over a lifetime. The massive presence of neuromelanin in these brain areas has long been suspected as a key factor involved in the selective vulnerability of neurons. The high concentration of neuromelanin in substantia nigra neurons seems to be linked to the presence of… Expand
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