Neuromelanin in human dopamine neurons: Comparison with peripheral melanins and relevance to Parkinson's disease

@article{Fedorow2005NeuromelaninIH,
  title={Neuromelanin in human dopamine neurons: Comparison with peripheral melanins and relevance to Parkinson's disease},
  author={H. Fedorow and F. Tribl and G. Halliday and M. Gerlach and K. Double},
  journal={Progress in Neurobiology},
  year={2005},
  volume={75},
  pages={109-124}
}
  • H. Fedorow, F. Tribl, +2 authors K. Double
  • Published 2005
  • Medicine, Biology
  • Progress in Neurobiology
  • Neuromelanin (NM) is a dark polymer pigment produced in specific populations of catecholaminergic neurons in the brain. It appears in greatest quantities in the human brain, in lesser amounts in some other non-human primates, but is absent from the brain in many lower species. Interest in this pigment has seen a resurgence in recent years because of a hypothesised link between neuromelanin and the especial vulnerability of neuromelanin-containing neurons to cell death in Parkinson's disease (PD… CONTINUE READING
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    References

    SHOWING 1-10 OF 173 REFERENCES
    The Melanoneurons of the Human Cerebellum (Nucleus Pigmentosus Cerebellaris) and Homologues in the Monkey
    • D. Cowen
    • Biology, Medicine
    • Journal of neuropathology and experimental neurology
    • 1986
    • 27
    The enigma of neuromelanin in Parkinson's disease substantia nigra.
    • 71
    A brainstem atlas of catecholaminergic neurons in man, using melanin as a natural marker
    • B. Bogerts
    • Biology, Medicine
    • The Journal of comparative neurology
    • 1981
    • 162
    Structural Characteristics of Human Substantia Nigra Neuromelanin and Synthetic Dopamine Melanins
    • 108
    • PDF
    Possible role of neuromelanin in the pathogenesis of Parkinson's disease
    • 201
    Neuromelanic pigment in substantia nigra neurons of rats and dogs
    • 35