Neuromelanin in human dopamine neurons: Comparison with peripheral melanins and relevance to Parkinson's disease

@article{Fedorow2005NeuromelaninIH,
  title={Neuromelanin in human dopamine neurons: Comparison with peripheral melanins and relevance to Parkinson's disease},
  author={Heidi Fedorow and Florian Tribl and Glenda M. Halliday and Manfred Gerlach and Peter Franz Riederer and Kay L. Double},
  journal={Progress in Neurobiology},
  year={2005},
  volume={75},
  pages={109-124}
}
Neuromelanin (NM) is a dark polymer pigment produced in specific populations of catecholaminergic neurons in the brain. It appears in greatest quantities in the human brain, in lesser amounts in some other non-human primates, but is absent from the brain in many lower species. Interest in this pigment has seen a resurgence in recent years because of a hypothesised link between neuromelanin and the especial vulnerability of neuromelanin-containing neurons to cell death in Parkinson's disease (PD… Expand
Neuromelanin, aging, and neuronal vulnerability in Parkinson's disease
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  • 2019
TLDR
The recent introduction of a rodent model exhibiting an age‐dependent production of human‐like neuromelanin has allowed, for the first time, the consequences of progressive neuromalanin accumulation—up to levels reached in elderly human brains—to be assessed in vivo. Expand
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  • Biology, Medicine
  • Journal of Neural Transmission
  • 2006
TLDR
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Tyrosinase is not detected in human catecholaminergic neurons by immunohistochemistry and Western blot analysis.
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TLDR
Electron paramagnetic resonance spectroscopy is used in the present study to show unambiguously that neuromelanin is a melanin; however, it is not well modeled by synthetic dopamine melanin and thus is an atypical melanin. Expand
Melanized dopaminergic neurons are differentially susceptible to degeneration in Parkinson's disease
TLDR
Quantitative analysis of neuromelanin-pigmented neurons in control and parkinsonian midbrains demonstrates that the dopamine-containing cell groups of the normal human midbrain differ markedly from each other in the percentage of neurmelan in-pIGmented neurons they contain, and suggests a selective vulnerability of the neuromelsin- pigmented subpopulation of dopamine- containing mesencephalic neurons in Parkinson's disease. Expand
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An atlas showing the distribution of melanin‐containing nerve cells in the human brainstem found that neuromelanin is suitable as a natural marker for catecholaminergic neurons in the medulla oblongata, pons, and the mesencephalon of the adult human brain. Expand
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TLDR
Results suggest that NM is a more complex pigment than synthetic dopaminemelanin formed via dopamine autoxidation alone, and suggests a peptide component in NMstructure. Expand
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It is suggested that neuromelanin can be phagocytised by neuronal cells which may thus be subjected to its toxic effects and contribute to the understanding of the formation and disposition of neuromalanin and its possible role in the etiology of Parkinson's disease. Expand
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TLDR
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TLDR
The findings suggest that the formation of neuromelanin in the substantia nigra involves MAO and non-enzymatic oxidative processes. Expand
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