Neuromelanin in human dopamine neurons: Comparison with peripheral melanins and relevance to Parkinson's disease

  title={Neuromelanin in human dopamine neurons: Comparison with peripheral melanins and relevance to Parkinson's disease},
  author={H. Fedorow and F. Tribl and G. Halliday and M. Gerlach and K. Double},
  journal={Progress in Neurobiology},
  • H. Fedorow, F. Tribl, +2 authors K. Double
  • Published 2005
  • Medicine, Biology
  • Progress in Neurobiology
  • Neuromelanin (NM) is a dark polymer pigment produced in specific populations of catecholaminergic neurons in the brain. It appears in greatest quantities in the human brain, in lesser amounts in some other non-human primates, but is absent from the brain in many lower species. Interest in this pigment has seen a resurgence in recent years because of a hypothesised link between neuromelanin and the especial vulnerability of neuromelanin-containing neurons to cell death in Parkinson's disease (PD… CONTINUE READING
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