Neuromelanin and iron in human locus coeruleus and substantia nigra during aging: consequences for neuronal vulnerability

@article{Zucca2006NeuromelaninAI,
  title={Neuromelanin and iron in human locus coeruleus and substantia nigra during aging: consequences for neuronal vulnerability},
  author={F. Zucca and C. Bellei and S. Giannelli and M. Terreni and M. Gallorini and E. Rizzio and G. Pezzoli and A. Albertini and L. Zecca},
  journal={Journal of Neural Transmission},
  year={2006},
  volume={113},
  pages={757-767}
}
Summary.In this study a comparative analysis of iron molecules during aging was performed in locus coeruleus (LC) and substantia nigra (SN), known targets of Parkinson’s Disease (PD) and related disorders. LC and SN neurons, especially the SN pars compacta, degenerate in PD and other forms of parkinsonism. Iron and its major molecular forms, such as ferritin and neuromelanin (NM), were measured in LC and SN of normal subjects at various ages. Iron levels were lower, H-ferritin/iron ratio was… Expand
Iron, the substantia nigra and related neurological disorders.
Locus Coeruleus Modulates Neuroinflammation in Parkinsonism and Dementia
Interactions of iron, dopamine and neuromelanin pathways in brain aging and Parkinson's disease
Neuromelanin of the Human Substantia Nigra: An Update
Unraveling the contributions to the neuromelanin-MRI contrast
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