Neuromedin S-Producing Neurons Act as Essential Pacemakers in the Suprachiasmatic Nucleus to Couple Clock Neurons and Dictate Circadian Rhythms

@article{Lee2015NeuromedinSN,
  title={Neuromedin S-Producing Neurons Act as Essential Pacemakers in the Suprachiasmatic Nucleus to Couple Clock Neurons and Dictate Circadian Rhythms},
  author={Ivan Tian-Guang Lee and A. Y. Chang and Manabu Manandhar and Yongli Shan and Junmei Fan and Mariko Izumo and Yuichi Ikeda and Toshiyuki Motoike and Shelley A Dixon and Jeffrey E. Seinfeld and Joseph S Takahashi and Masashi Yanagisawa},
  journal={Neuron},
  year={2015},
  volume={85},
  pages={1086-1102}
}
Circadian behavior in mammals is orchestrated by neurons within the suprachiasmatic nucleus (SCN), yet the neuronal population necessary for the generation of timekeeping remains unknown. We show that a subset of SCN neurons expressing the neuropeptide neuromedin S (NMS) plays an essential role in the generation of daily rhythms in behavior. We demonstrate that lengthening period within Nms neurons is sufficient to lengthen period of the SCN and behavioral circadian rhythms. Conversely, mice… CONTINUE READING