Neuromedin B receptors retain functional expression when transfected into BALB 3T3 fibroblasts: analysis of binding, kinetics, stoichiometry, modulation by guanine nucleotide-binding proteins, and signal transduction and comparison with natively expressed receptors.

@article{Benya1992NeuromedinBR,
  title={Neuromedin B receptors retain functional expression when transfected into BALB 3T3 fibroblasts: analysis of binding, kinetics, stoichiometry, modulation by guanine nucleotide-binding proteins, and signal transduction and comparison with natively expressed receptors.},
  author={Richard V. Benya and Etsuko Wada and James F. Battey and Zahra Fathi and Lei Wang and Samuel A. Mantey and D. H. Coy. E. J. Coy and Robert Thomas Jensen},
  journal={Molecular pharmacology},
  year={1992},
  volume={42 6},
  pages={1058-68}
}
The receptor that interacts with the mammalian bombesin-related peptide neuromedin B (NMB) is ubiquitous in the gastrointestinal tract and central nervous system. However, little is known regarding its cellular mechanisms of action. This receptor has been recently cloned, sequenced, and stably transfected into BALB 3T3 fibroblasts, permitting detailed study of the pharmacology and coupled biological activities of this receptor. In the present study, we compare the ability of transfected… CONTINUE READING
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