Neuromedin B receptors regulate EGF receptor tyrosine phosphorylation in lung cancer cells.

@article{Moody2010NeuromedinBR,
  title={Neuromedin B receptors regulate EGF receptor tyrosine phosphorylation in lung cancer cells.},
  author={Terry W. Moody and Marc Jean Berna and Samuel A. Mantey and Veronica Sancho and Lisa A. Ridnour and David A Wink and Daniel Siu Hhung Chan and Guiseppe Giaccone and Robert Thomas Jensen},
  journal={European journal of pharmacology},
  year={2010},
  volume={637 1-3},
  pages={38-45}
}
Neuromedin B (NMB), a member of the bombesin family of peptides, is an autocrine growth factor for many lung cancer cells. The present study investigated the ability of NMB to cause transactivation of the epidermal growth factor (EGF) receptor in lung cancer cells. By Western blot, addition of NMB or related peptides to NCI-H1299 human non-small cell lung cancer (NSCLC) cells, caused phosphorylation of Tyr(1068) of the EGF receptor. The signal was amplified using NCI-H1299 cells stably… CONTINUE READING