Neurology of Tourette's syndrome (TS) TS as a developmental dopamine disorder: a hypothesis

@article{Nomura2003NeurologyOT,
  title={Neurology of Tourette's syndrome (TS) TS as a developmental dopamine disorder: a hypothesis},
  author={Yoshiko Nomura and Masaya Segawa},
  journal={Brain and Development},
  year={2003},
  volume={25},
  pages={s37-s42}
}
The favorable effect of dopamine (DA) depletors or DA receptor blockers suggested the state of increased transmission of DA system as the pathophysiology of Tourette's syndrome (TS). We have analysed the neurological signs of TS and evaluated the role of levodopa on the symptoms of TS. The data were compared with age-matched patients with Hereditary Progressive Dystonia (HPD) with marked diurnal fluctuation. Neurological examination of 81 drug naive TS patients revealed the clumsiness of rapid… CONTINUE READING

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