Neurology and neuropsychiatry of COVID-19: a systematic review and meta-analysis of the early literature reveals frequent CNS manifestations and key emerging narratives

@article{Rogers2021NeurologyAN,
  title={Neurology and neuropsychiatry of COVID-19: a systematic review and meta-analysis of the early literature reveals frequent CNS manifestations and key emerging narratives},
  author={Jonathan P Rogers and Cameron J. Watson and James Badenoch and Benjamin Cross and Matthew Butler and Jia Song and Danish Hafeez and Hamilton Morrin and Emma Rachel Rengasamy and Lucretia Thomas and Silviya Ralovska and Abigail Smakowski and Ritika Dilip Sundaram and Camille K. Hunt and Mao Fong Lim and Daruj Aniwattanapong and Vanshika Singh and Zain U. Hussain and Stuti Chakraborty and Ella Burchill and Katrin Jansen and Heinz Holling and Dean Walton and Thomas A. Pollak and Mark Ellul and Ivan Koychev and Tom Solomon and Benedict Daniel Michael and Timothy R. Nicholson and Alasdair G. Rooney},
  journal={Journal of Neurology, Neurosurgery, and Psychiatry},
  year={2021},
  volume={92},
  pages={932 - 941}
}
There is accumulating evidence of the neurological and neuropsychiatric features of infection with SARS-CoV-2. In this systematic review and meta-analysis, we aimed to describe the characteristics of the early literature and estimate point prevalences for neurological and neuropsychiatric manifestations. We searched MEDLINE, Embase, PsycINFO and CINAHL up to 18 July 2020 for randomised controlled trials, cohort studies, case-control studies, cross-sectional studies and case series. Studies… Expand
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References

SHOWING 1-10 OF 43 REFERENCES
The neurology and neuropsychiatry of COVID-19: a systematic review and meta-analysis of the early literature reveals frequent CNS manifestations and key emerging narratives
Objectives There is accumulating evidence of the neurological and neuropsychiatric features of infection with SARS-CoV-2. In this systematic review and meta-analysis, we aimed to describe theExpand
Neurological manifestations of COVID-19: a systematic review and meta-analysis of proportions
TLDR
Identifying some neurological manifestations like smell and taste disturbances can be used to screen patients with COVID-19 so that early identification and isolation is possible. Expand
Psychiatric and neuropsychiatric presentations associated with severe coronavirus infections: a systematic review and meta-analysis with comparison to the COVID-19 pandemic
TLDR
The systematic review and meta-analysis revealed that during the acute illness, common symptoms among patients admitted to hospital for SARS or MERS included confusion and depression, and in one study traumatic memories. Expand
Clinical manifestations and evidence of neurological involvement in 2019 novel coronavirus SARS-CoV-2: a systematic review and meta-analysis
TLDR
Lab, electrophysiological, radiological, and pathological evidence supported neurologic involvement of COVID-19, suggesting neurological involvement is an important aspect of the disease. Expand
Neurologic Characteristics in Coronavirus Disease 2019 (COVID-19): A Systematic Review and Meta-Analysis
TLDR
Doctors should be aware of the presence of neurologic signs and symptoms as a chief complaint of COVID-19, in order to improve management and prevent a worsening outcome of the patients, according to the Oxford Center for Evidence-Based Medicine guidelines. Expand
Neurological and neuropsychiatric complications of COVID-19 in 153 patients: a UK-wide surveillance study
TLDR
This is the first nationwide, cross-specialty surveillance study of acute neurological and psychiatric complications of COVID-19 and provides valuable and timely data that are urgently needed by clinicians, researchers, and funders. Expand
Prevalence of Headache in Patients With Coronavirus Disease 2019 (COVID-19): A Systematic Review and Meta-Analysis of 14,275 Patients
TLDR
From the first 4-month data of the outbreak, headache was detected in 10.1% of the adult COVID-19 patients, with no significant difference of headache prevalence in severe or critical vs. non-severe patients. Expand
A prospective clinical study of detailed neurological manifestations in patients with COVID-19
TLDR
Headache was the most common seen neurological symptom in this disease and it is suggested that determining these neurological symptoms prevents the diagnosis delay and helps to prohibit virus spread. Expand
Early neurological manifestations of hospitalized COVID-19 patients
TLDR
Headache in association with arthralgia and muscle pain seems to reflect the common symptoms of the flu-like syndrome, and not COVID-19 infection-specific, as well as the possible relationship between plasmatic inflammatory indices and olfactory disorders (ODs), muscle pain and creatine kinase (CK). Expand
Guillain-Barré syndrome associated with SARS-CoV-2 infection: causality or coincidence?
TLDR
The patient’s initial labor abnorma lities, which were consistent with clinical characteristics of patients with COVID-19, indicated the presence of SARS-CoV-2 infection on admission, and it is considered that the virus was transmitted to her relatives dur ing her hospital stay. Expand
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