Neurological soft signs in familial and sporadic schizophrenia

@article{Fountoulakis2019NeurologicalSS,
  title={Neurological soft signs in familial and sporadic schizophrenia},
  author={Konstantinos N. Fountoulakis and Panagiotis Panagiotidis and Vasilios K. Kimiskidis and Ioannis Nimatoudis and X{\'e}nia Gonda},
  journal={Psychiatry Research},
  year={2019},
  volume={272},
  pages={222-229}
}
Paternal age and specific neurological soft signs as reliable and valid neurobiological markers for the diagnosis of patients with schizophrenia
TLDR
The current is probably the first study to report on an easily obtainable diagnostic neurobiological marker with identifiable properties which is absolutely independent from the clinical manifestations and could serve in distinguishing between patients with schizophrenia and healthy controls with high efficacy.
Detection of Morphological Abnormalities in Schizophrenia: An Important Step to Identify Associated Genetic Disorders or Etiologic Subtypes
TLDR
Evidence of genetic contributions to schizophrenia and current knowledge on genetic syndromes associated with this psychiatric disorder highlight the importance of a clinical genetic examination to detect minor physical anomalies in individuals with ultra-high risk of schizophrenia.
One-year Outcome of First vs. Later Episode Schizophrenia: A Real-world Naturalistic Study
TLDR
Very low rates of remission and recovery of patients with schizophrenia without any differences between FES and non-FES patients are reported, suggesting that early lack of remission is not prognostic of a poor outcome.
The effect of baseline antipsychotic status on the 12‐month outcome in initially stabilized patients with schizophrenia
TLDR
The aim of the study was to measure the real‐life effect of antipsychotic treatment on remission and recovery rates in already stabilized patients with schizophrenia after 1 year.
12-Month stability of neurological soft signs in stabilized patients with schizophrenia
TLDR
The results of the current study suggest that after stabilization of patients with schizophrenia, there are probably two separate components, a ’trait’ which is stable over a 12-month period, and a ‘degenerative’ component with a tendency to worsen probably in parallel with the progression of the illness and in correlation with the worsening of negative symptoms.

References

SHOWING 1-10 OF 94 REFERENCES
Neurological soft signs significantly differentiate schizophrenia patients from healthy controls
TLDR
It is suggested that NSS constitute an independent (from the rest of symptoms), core (present in the vast majority of patients) and trait (unrelated to age and probably to the stage of schizophrenia) symptom of schizophrenia which could be of value in the clinical assessment and research of schizophrenia.
Neurological Soft Signs in the Clinical Course of Schizophrenia: Results of a Meta-Analysis
TLDR
From a clinical perspective, NSS may be used to identify subjects at risk to develop schizophrenia and to monitor disease progression and NSS scores did not decrease to the level typically observed in healthy controls.
Relative risk of neurological signs in siblings of patients with schizophrenia.
TLDR
These data suggest that neurological signs cluster in patients with schizophrenia and their families and could possibly identify a unique component of genetic variance for risk of schizophrenia, however, the fairly low relative risk and the uncertain pathophysiology of such signs may limit their usefulness.
Neurological soft signs might be endophenotype candidates for patients with deficit syndrome schizophrenia
TLDR
This study confirms that NSS were higher in patients with DS, and suggests that large sampled, multicentric studies are needed to clarify the place of NSS as an endophenotype in DS.
Neurological soft signs in first-episode schizophrenia: a follow-up study.
TLDR
Although neurological soft signs are intrinsic to schizophrenia, their level varies with the clinical course, and may be considered as potential predictors of outcome.
A systematic review and meta-analysis of neurological soft signs in relatives of people with schizophrenia
TLDR
Both hypotheses were confirmed, suggesting that the distribution of neurological soft signs in people with schizophrenia and their first-degree relatives is consistent with the endophenotype criterion of familial association.
...
...