Neurological functional recovery after thymosin beta4 treatment in mice with experimental auto encephalomyelitis.

@article{Zhang2009NeurologicalFR,
  title={Neurological functional recovery after thymosin beta4 treatment in mice with experimental auto encephalomyelitis.},
  author={Jing Zhang and Zheng Gang Zhang and Daniel Morris and Y-q Li and Cynthia Roberts and Stanton Bernard Elias and Michael Chopp},
  journal={Neuroscience},
  year={2009},
  volume={164 4},
  pages={1887-93}
}
In the present study, we hypothesized that thymosin beta 4 (Tbeta4) is a potential therapy of multiple sclerosis (MS). To test this hypothesis, SJL/J mice (n=21) were subjected to experimental autoimmune encephalomyelitis (EAE), an animal model of MS. EAE mice were treated with saline or Tbeta4 (6 mg/kg, n=10) every 3 days starting on the day of myelin proteolipid protein (PLP) immunization for total five doses. Neurological function, inflammatory infiltration, oligodendrocyte progenitor cells… CONTINUE READING
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