Neurological dysfunction and hyperactive behavior associated with antiphospholipid antibodies. A mouse model.

@article{Ziporen1997NeurologicalDA,
  title={Neurological dysfunction and hyperactive behavior associated with antiphospholipid antibodies. A mouse model.},
  author={Lea Ziporen and Yehuda Shoenfeld and Yehuda Levy and Amos D. Korczyn},
  journal={The Journal of clinical investigation},
  year={1997},
  volume={100 3},
  pages={613-9}
}
Antiphospholipid antibodies (aPL) have been associated with various neurological manifestations, but the underlying mechanism has not been elucidated. We assessed mice with induced experimental antiphospholipid syndrome (APS) for neurological and behavioral changes. After immunization with monoclonal human anticardiolipin antibody (H-3), female BALB/c mice developed elevated levels of circulating anti-negatively charged phospholipids (aPL), anti-beta2-glycoprotein I (abeta2GPI), and anti… CONTINUE READING

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