Neurological disorders caused by inherited ion-channel mutations.

  title={Neurological disorders caused by inherited ion-channel mutations.},
  author={Dimitri Michael Kullmann and Michael G. Hanna},
  journal={The Lancet. Neurology},
  volume={1 3},
Several neurological diseases-including neuromuscular disorders, movement disorders, migraine, and epilepsy-are caused by inherited mutations of ion channels. The list of these "channelopathies" is expanding rapidly, as is the phenotypic range associated with each channel. At present the best understood channelopathies are those that affect muscle-fibre excitability. These channelopathies produce a range of disorders which include: periodic paralysis, myotonias, malignant hyperthermia, and… CONTINUE READING


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