Neurological disorders: Inhibition: too much of a good thing?

  title={Neurological disorders: Inhibition: too much of a good thing?},
  author={Katherine Whalley},
  journal={Nature Reviews Neuroscience},
  • K. Whalley
  • Published 2010
  • Biology, Psychology
  • Nature Reviews Neuroscience
a spike and wave discharge (SWD) pattern in thalamocortical networks, occur in many types of epilepsy. The cellular mechanisms underlying these seizures are unclear; however, a new paper by Cope et al. reveals that enhanced neuronal inhibition causes seizures in several animal models of absence epilepsy. It has been suggested that reduced GABA (γ-aminobutyric acid) type A receptor (GABAAR)mediated inhibition might cause absence seizures; however, there is confounding evidence for this… 


Enhanced tonic GABAA inhibition in typical absence epilepsy

It is shown that extrasynaptic GABAA receptor–dependent 'tonic' inhibition is increased in thalamocortical neurons from diverse genetic and pharmacological models of absence seizures, identifying an apparently common cellular pathology in typical absence seizures that may have epileptogenic importance and highlight potential therapeutic targets for the treatment of absence epilepsy.