Neurological diseases: Targeting programmed cell death in neurodegenerative diseases

  title={Neurological diseases: Targeting programmed cell death in neurodegenerative diseases},
  author={M. Vila and S. Przedborski},
  journal={Nature Reviews Neuroscience},
  • M. Vila, S. Przedborski
  • Published 2003
  • Biology, Medicine
  • Nature Reviews Neuroscience
  • Molecular pathways of programmed cell death (PCD) are activated in various neurodegenerative disorders including Parkinson's disease, amyotrophic lateral sclerosis and Huntington's disease. In these diseases, PCD might be pathogenic, and targeting it might mitigate neurodegeneration. To identify potential neuroprotective targets within the PCD machinery, the expression and activity of some of its components have been altered by genetic or pharmacological means in experimental models of… CONTINUE READING
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