Neurological diseases: Targeting programmed cell death in neurodegenerative diseases

@article{Vila2003NeurologicalDT,
  title={Neurological diseases: Targeting programmed cell death in neurodegenerative diseases},
  author={M. Vila and S. Przedborski},
  journal={Nature Reviews Neuroscience},
  year={2003},
  volume={4},
  pages={365-375}
}
  • M. Vila, S. Przedborski
  • Published 2003
  • Biology, Medicine
  • Nature Reviews Neuroscience
  • Molecular pathways of programmed cell death (PCD) are activated in various neurodegenerative disorders including Parkinson's disease, amyotrophic lateral sclerosis and Huntington's disease. In these diseases, PCD might be pathogenic, and targeting it might mitigate neurodegeneration. To identify potential neuroprotective targets within the PCD machinery, the expression and activity of some of its components have been altered by genetic or pharmacological means in experimental models of… CONTINUE READING
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    • Medicine
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    • Medicine
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    References

    SHOWING 1-10 OF 191 REFERENCES
    Apoptosis and autophagy in nigral neurons of patients with Parkinson's disease.
    • 936
    • PDF
    Histochemical detection of apoptosis in Parkinson's disease
    • 456
    Evidence for apoptotic cell death in Huntington disease and excitotoxic animal models
    • 621
    • PDF
    Programmed Cell Death in Cerebral Ischemia
    • S. Graham, J. Chen
    • Medicine, Biology
    • Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
    • 2001
    • 449
    • PDF
    Apoptosis is induced by beta-amyloid in cultured central nervous system neurons.
    • 1,027
    • PDF
    Neuronal death in amyotrophic lateral sclerosis is apoptosis: possible contribution of a programmed cell death mechanism.
    • L. Martin
    • Medicine, Biology
    • Journal of neuropathology and experimental neurology
    • 1999
    • 345
    • PDF