Neurological and neurophysiological examinations on workers with chronic poisoning by 2,3,7,8‐TCDD: follow‐up 35 years after exposure

@article{Urban2007NeurologicalAN,
  title={Neurological and neurophysiological examinations on workers with chronic poisoning by 2,3,7,8‐TCDD: follow‐up 35 years after exposure},
  author={Pavel Urban and Daniela Pelclova and Edgar Luk{\'a}{\vs} and Karel Kupka and Jan C Prei{\ss} and Zdenka Fenclov{\'a} and Zdeněk {\vS}merhovsk{\'y}},
  journal={European Journal of Neurology},
  year={2007},
  volume={14}
}
Between 1965 and 1968, about 350 workers were accidentally exposed to 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin (TCDD) in a chemical plant, which was producing herbicides based on the trichlorophenoxyacetic acid. About 80 workers developed signs of poisoning. The estimated mean concentration of TCDD at the time of exposure was about 5000 pg/g of plasma fat. Only 15 subjects from the original cohort remained available for the recent follow‐up in 2004. All were men, mean age 60 years. The mean current… 
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The last eight survivors of 80 workers accidentally exposed to 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin (TCDD) during production of herbicides based on trichlorophenoxyacetic acid in 1965–1967 in a
Diabetes, Cardiovascular Disorders and 2,3,7,8‐Tetrachlorodibenzo‐p‐Dioxin Body Burden in Czech Patients 50 Years After the Intoxication
TLDR
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To measure specific regional brain functional findings with SPECT on seven patients with various encephalopathic diseases and occupational and/or environmental chemical exposure, single Photon Emission Computed Tomography is used.
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Dioxin exposure during the perinatal period and in adulthood may alter regional brain volume, which might lead to cognitive deficits and unusual social emotional behavior in Vietnamese men living in dioxin-contaminated areas.
[Usefulness of color vision test for early detection of neurological damages by neurotoxic substances].
TLDR
The test for color vision impairment is known to be very sensitive to the early signs of nervous system dysfunction and this can be useful for making the early diagnosis of neurotoxic effects from exposure to very low concentrations of toxic substances.
Exhaled breath condensate biomarkers reflect systemic changes in patients with chronic dioxin intoxication
TLDR
Differences in the expression of the biomolecular markers in EBC as compared to controls were not associated with lung impairments and the respiratory parameters measured, and these EBC markers can be used to evaluate systemic oxidative stress and inflammation in tissues and the endovascular, atherosclerotic, neurotoxic, and metabolic effects of TCDD.
2,3,7,8‐tetrachlorodibenzo‐p‐dioxin exposure influence the expression of glutamate transporter GLT‐1 in C6 glioma cells via the Ca2+/protein kinase C pathway
TLDR
The results suggested that TCDD exposure could downregulate the expression of GLT‐1 in C6 via Ca2+/PKC pathway, which might participate in T CDD‐mediated neurotoxicity.
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TLDR
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TLDR
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TLDR
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TLDR
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