Neurological abnormalities in a knock-in mouse model of Huntington's disease.

@article{Lin2001NeurologicalAI,
  title={Neurological abnormalities in a knock-in mouse model of Huntington's disease.},
  author={Chia Hsun Lin and Sara J Tallaksen-Greene and W M Chien and Jamie A. Cearley and Walker S. Jackson and Andrew B Crouse and Shuxun Ren and Xshang Li and Roger L Albin and Peter J Detloff},
  journal={Human molecular genetics},
  year={2001},
  volume={10 2},
  pages={137-44}
}
Mice representing precise genetic replicas of Huntington's disease (HD) were made using gene targeting to replace the short CAG repeat of the mouse Huntington's disease gene homolog (HDH:) with CAG repeats within the length range found to cause HD in humans. Mice with alleles of approximately 150 units in length exhibit late-onset behavioral and neuroanatomic abnormalities consistent with HD. These symptoms include a motor task deficit, gait abnormalities, reactive gliosis and the formation of… CONTINUE READING
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