Neurological abnormalities in a knock-in mouse model of Huntington's disease.

  title={Neurological abnormalities in a knock-in mouse model of Huntington's disease.},
  author={Chia Hsun Lin and Sara J Tallaksen-Greene and W M Chien and Jamie A. Cearley and Walker S. Jackson and Andrew B Crouse and Shuxun Ren and Xshang Li and Roger L Albin and Peter J Detloff},
  journal={Human molecular genetics},
  volume={10 2},
Mice representing precise genetic replicas of Huntington's disease (HD) were made using gene targeting to replace the short CAG repeat of the mouse Huntington's disease gene homolog (HDH:) with CAG repeats within the length range found to cause HD in humans. Mice with alleles of approximately 150 units in length exhibit late-onset behavioral and neuroanatomic abnormalities consistent with HD. These symptoms include a motor task deficit, gait abnormalities, reactive gliosis and the formation of… CONTINUE READING
Highly Influential
This paper has highly influenced 25 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS


Publications citing this paper.
Showing 1-10 of 247 extracted citations

Similar Papers

Loading similar papers…