Corpus ID: 235390700

Neurological Consequences of COVID-19 Infection

  title={Neurological Consequences of COVID-19 Infection},
  author={Jia-Liang Tang and Shivani A. Patel and Steve Gentleman and P. C. Matthews},
COVID-19 infections have well described systemic manifestations, especially respiratory problems. There are currently no specific treatments or vaccines against the current strain. With higher case numbers, a range of neurological symptoms are becoming apparent. The mechanisms responsible for these are not well defined, other than those related to hypoxia and microthrombi. We speculate that sustained systemic immune activation seen with SARS-CoV-2 may also cause secondary autoimmune activation… Expand

Figures from this paper


Nervous system involvement after infection with COVID-19 and other coronaviruses
The research into neurological complications in CoV infections and the possible mechanisms of damage to the nervous system are reviewed. Expand
Adamantanes might be protective from COVID-19 in patients with neurological diseases: multiple sclerosis, parkinsonism and cognitive impairment
A questionnaire-based study performed to assess severity of COVID-19 in patients suffering from multiple sclerosis, Parkinson's disease or cognitive impairment, finding that subjects suffering from neurological disease did not report any significant changes in neurological status in the course of primary nervous system disease. Expand
Steroid‐responsive encephalitis in Covid‐19 disease
A progressive clinical improvement along with a reduction of cerebrospinal fluid parameters was observed after high‐dose steroid treatment, thus arguing for an inflammatory‐mediated brain involvement related to COVID‐19. Expand
Outcome of Parkinson's Disease Patients Affected by COVID‐19
Findings suggest that PD patients of older age are particularly susceptible to COVID-19 with a substantially high mortality rate and those on advanced therapies, such as deep brain stimulation or levodopa infusion therapy, seem especially vulnerable, and a mortality rate of 50% among such cases is of concern. Expand
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and the Central Nervous System
Given the global dimension of the current pandemic, the need to consider the possible long-term impact of COVID-19 is highlighted, potentially including neurological and neurodegenerative disorders. Expand
Subjective neurological symptoms frequently occur in patients with SARS-CoV2 infection
Patients with SARS-CoV2 infection frequently present with subjective neurological symptoms (sNS), and laboratory findings correlated with the occurrence of hyposmia, dysgeusia, headache, daytime sleepiness, and depression. Expand
Evidence of the COVID-19 Virus Targeting the CNS: Tissue Distribution, Host–Virus Interaction, and Proposed Neurotropic Mechanisms
The density of the expression levels of ACE2 in the CNS, the host–virus interaction and relate it to the pathogenesis and complications seen in the recent cases resulting from the COVID-19 outbreak are investigated. Expand
Lethal Infection of K18-hACE2 Mice Infected with Severe Acute Respiratory Syndrome Coronavirus
It is shown that transgenic mice that express the SARS-CoV receptor (human angiotensin-converting enzyme 2 [hACE2]) in airway and other epithelia develop a rapidly lethal infection after intranasal inoculation with a human strain of the virus. Expand
Human coronaviruses: Viral and cellular factors involved in neuroinvasiveness and neuropathogenesis
Host and viral factors that participate in the regulation of the possible pathogenic processes associated with CNS infection by human coronaviruses are presented and the intricate interplay between virus and host target cells is tried in order to characterize their role in the virus life cycle as well as in the capacity of the cell to respond to viral invasion. Expand
Are we facing a crashing wave of neuropsychiatric sequelae of COVID-19? Neuropsychiatric symptoms and potential immunologic mechanisms
Prospective neuropsychiatric monitoring of individuals exposed to SARS-CoV-2 at various points in the life course, as well as their neuroimmune status, are needed to fully understand the long-term impact of COVID-19, and to establish a framework for integrating psychoneuroimmunology into epidemiologic studies of pandemics. Expand