• Corpus ID: 201994100

Neurological Aspects of THC as a Treatment for Generalized Anxiety

  title={Neurological Aspects of THC as a Treatment for Generalized Anxiety},
  author={K V Kelly},



The endocannabinoid system in anxiety, fear memory and habituation

Both for anxiety and fear memory processing, endocannabinoid signalling may ensure an appropriate reaction to stressful events, and the ECS can be considered as a regulatory buffer system for emotional responses.

Correlated species differences in the effects of cannabinoid ligands on anxiety and on GABAergic and glutamatergic synaptic transmission

This is the first study showing that the relative cannabinoid sensitivity of GABA and glutamate neurotransmission is species‐dependent, and it is hypothesized that WIN‐55,212 reduced anxiety in mice by affecting GABA neurotransmission whereas it increased anxiety in rats via glutamatergic mechanisms.

Cannabis sativa and Cannabis indica versus “Sativa” and “Indica”

Phytochemical and genetic research supports the separation of “Sativa” and “Indica,” but their nomenclature does not align with formal botanical C. sativa and C. indica based on the protologues of Linnaeus and Lamarck.

Therapeutic potential of medicinal marijuana: an educational primer for health care professionals

The purpose of this paper is to offer physicians an educational tool that provides a necessary, evidence-based analysis of the therapeutic potential of MM and to ensure physicians are making decisions on the therapeutic use of MM in good faith.

Emerging drugs for the treatment of anxiety

This review will provide a critical summary of current pharmacological approaches to the treatment of anxiety and will examine the pharmacotherapeutic pipeline for treatments in development.

An Update on Non-CB1, Non-CB2 Cannabinoid Related G-Protein-Coupled Receptors

Insight is provided into the non- CB1, non-CB2 cannabinoid-related GPCRs that have been reported thus far to consider the physiological relevance of these molecular targets in modulating the ECS.

Cannabinoid Receptors and the Endocannabinoid System: Signaling and Function in the Central Nervous System

It is believed that the therapeutic significance of cannabinoids is masked by the adverse effects and here alternative strategies are discussed to take therapeutic advantage of cannabinoids.

Interaction Between the Cannabinoid and Vanilloid Systems on Anxiety in Male Rats

The results suggest that two systems could act on or share a common signaling pathway affecting the expression of anxiety, and antagonism of the vanilloid system modulates cannabinoid gain that rises the anxiolytic effect.

The therapeutic potential of drugs that target cannabinoid receptors or modulate the tissue levels or actions of endocannabinoids

Evidence is summarized that there are certain central and peripheral disorders in which increases take place in the release of endocannabinoids onto their receptors and/or in the density or coupling efficiency of these receptors and that this upregulation is protective in some disorders but can have undesirable consequences in others.