Neurologic manifestations of Lyme disease, the new "great imitator".

  title={Neurologic manifestations of Lyme disease, the new "great imitator".},
  author={Andrew R. Pachner},
  journal={Reviews of infectious diseases},
  volume={11 Suppl 6},
  • A. Pachner
  • Published 1 September 1989
  • Medicine
  • Reviews of infectious diseases
The causative agent of Lyme disease, Borrelia burgdorferi, is a highly neurotropic organism that not only can produce symptomatic neurologic disease but also can exist dormant within the central nervous system (CNS) for long periods. Two distinct types of neuroborreliosis occur at different stages of Lyme disease. Second-stage Lyme meningitis resembles aseptic meningitis and is often associated with facial palsies, peripheral nerve involvement, and/or radiculopathies. Lyme meningitis may be the… 

Lyme neuroborreliosis manifesting as an intracranial mass lesion.

A 10-year-old child with signs, symptoms, and radiological manifestations of intracranial mass lesions, without previously recognized manifestations of Lyme disease, proved to be Lyme neuroborreliosis, documented by histological and serological examination, which responded well to antibiotic therapy.

Lyme disease: a neuropsychiatric illness.

OBJECTIVE Lyme disease is a multisystemic illness that can affect the central nervous system (CNS), causing neurologic and psychiatric symptoms. The goal of this article is to familiarize

Nervous System Lyme Disease.

  • J. Halperin
  • Medicine, Biology
    Clinics in laboratory medicine
  • 2015

Atypical Case of Lyme Neuroborreliosis With Hyponatremia

This case report describes a 58-year-old woman who developed progressive lower extremity weakness and paresthesia, cerebellar ataxia, and persistent hyponatremia and was diagnosed and treated with 2mg ceftriaxone from clinical suspicion.

Neuroborreliosis in the nonhuman primate: Borrelia burgdorferi persists in the central nervous system

Data suggest that Lyme neuroboreliosis represents persistent infection with B. burgdorferi in the central nervous system, and that the organism has a predilection toward subtentorial structures.

Chronic Lyme Disease: A Working Case Definition

A working case definition of CLD is presented based on analysis of more than 700 peer-reviewed publications that indicates chronic Lyme disease is a multisystem illness with diverse musculoskeletal, neuropsychiatric and/or cardiovascular manifestations that result from ongoing infection with pathogenic members of the Borrelia spirochete complex.

Late-stage neuropsychiatric Lyme borreliosis. Differential diagnosis and treatment.

Treponematosis and Lyme borreliosis connections: explanation for Tchefuncte disease syndromes?

  • B. Lewis
  • Medicine, Biology
    American journal of physical anthropology
  • 1994
A convergence of evidence from macroscopic, radiographic and histologic examination indicates that treponemal infection was present in the 16ST1 Tchefuncte Indian burial population, dated 500 B.C. to 300 A.D, and that presence of the Borrelia burgdorferi spirochete might be linked to a single incidence of juvenile rheumatoid arthritis.



The early clinical manifestations of Lyme disease.

Patients with Lyme disease sometimes had evidence of meningeal irritation, mild encephalopathy, migratory musculoskeletal pain, hepatitis, generalized lymphadenopathy and splenomegaly, sore throat, nonproductive cough, or testicular swelling, and signs and symptoms were typically intermittent and changing during a period of several weeks.

The triad of neurologic manifestations of Lyme disease

Although sometimes incomplete, the triad of neurologic manifestations of Lyme disease— meningitis, cranial neuritis, and radiculoneuritis—presents a unique clinical picture.

Unusual manifestations of nervous system Borrelia burgdorferi infection.

Serologic analyses (enzyme-linked immunosorbent assay) in serum and cerebrospinal fluid should be performed widely in cases with inflammatory findings in cerebro Spinal fluid combined with neurologic disease of unclear origins.

Bannwarth's syndrome and the enlarged neurological spectrum of arthropod-borne borreliosis.

Spirochetal diseases of the CNS.

Antibiotic therapy in Lyme disease.

It is concluded that penicillin therapy shortens the duration of erythema chronicum migrans and may prevent or attenuate subsequent arthritis.

Neurologic abnormalities of Lyme disease: successful treatment with high-dose intravenous penicillin.

High-dose intravenous penicillin is effective therapy for neurologic abnormalities of Lyme disease and the duration of meningitic syndrome was significantly shorter in those givenPenicillin.

An Animal Model for Lyme Arthritis a

A model of Lyme arthritis has been developed in laboratory rats and shows features of the Lyme disease complex have yet to be seen in the rat, but long-term studies are required to completely define the rat model.