Neurologic damage and neurocognitive dysfunction in urea cycle disorders.

@article{Enns2008NeurologicDA,
  title={Neurologic damage and neurocognitive dysfunction in urea cycle disorders.},
  author={Gregory M. Enns},
  journal={Seminars in pediatric neurology},
  year={2008},
  volume={15 3},
  pages={132-9}
}
Although the survival of patients who have urea cycle disorders has improved with the use of modalities such as alternative pathway therapy and hemodialysis, neurologic outcome is suboptimal. Patients often manifest with a variety of neurologic abnormalities, including cerebral edema, seizures, cognitive impairment, and psychiatric illness. Current hypotheses of the pathogenesis underlying brain dysfunction in these patients have focused on several lines of investigation, including the role of… CONTINUE READING

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