Neurologic complications of chemotherapy agents

@article{Kannarkat2007NeurologicCO,
  title={Neurologic complications of chemotherapy agents},
  author={George Kannarkat and Erin E. Lasher and David Schiff},
  journal={Current Opinion in Neurology},
  year={2007},
  volume={20},
  pages={719–725}
}
Purpose of reviewTo review neurologic complications of common and recently developed chemotherapeutic agents, as well as recent research regarding ‘chemobrain’. Recent findingsBortezomib, a new anticancer agent, has a propensity toward causing a largely sensory and reversible peripheral neuropathy. Infusion of magnesium and calcium pre and post-oxaliplatin infusion reduces neuropathy but may interfere with clinical response to oxaliplatin. No other measures currently reduce the incidence or… 
Chemotherapy-induced neurotoxicity: the value of neuroprotective strategies.
TLDR
Several neuroprotective strategies have been investigated to decrease the neurotoxicity without compromising anti-tumour efficacy, with calcium/magnesium infusion, amifostine, gluthatione, glutamine, acetyl-L-carnitine and erythropoietin as most promising.
Neurotoxicity of chemotherapy
Animal models of chemotherapy-evoked painful peripheral neuropathies
Nutraceuticals for Prevention of Chemotherapy-Induced Peripheral Neuropathy
TLDR
The authors analyze the potential applications of nutrients, dietary supplements and herbal products, such as single herbs, the Kampo medicine goshajinkigan and other herbal combinations, for CIPN prevention.
Neurochemical characterization of primary sensory neurons in a rat model of bortezomic-induced peripheral neuropathy
TLDR
The characterization of this animal model of chemotherapy-induced peripheral neuropathy suggests that the neurochemical changes occurring in populations of DRG neurons that are likely involved in pain transmission appear to be an important component of the sensory neuropathy induced by the bortezomib-treatment and may represent the outcome of the molecular machine activated by the drug during the onset and persistence of bortzomib -induced neuropathic pain.
Post-chemotherapy cognitive impairment in hematological patients: current understanding of chemobrain in hematology
TLDR
This review has examined some commonly used drugs for the treatment of hematological malignancies which are known to have a deleterious action on cognitive functions and the interactions between genetic risk, amyloid accumulation, intrinsic brain networks, and chemotherapy.
An Overview of Chemotherapy-Induced Peripheral Neuropathy
TLDR
Peripheral neuropathy remains a major limitation of chemotherapeutic agents used in cancer treatment and prompt recognition and evaluation by those who provide care to patients with cancer can prove to have a positive impact on the quality of life of those patients.
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TLDR
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