Neuroligins Determine Synapse Maturation and Function

  title={Neuroligins Determine Synapse Maturation and Function},
  author={Frederique Varoqueaux and Gayane Aramuni and Randi L. Rawson and Ralf Mohrmann and Markus Missler and Kurt Gottmann and Weiqi Zhang and Thomas C S{\"u}dhof and Nils Brose},
Synaptogenesis, the generation and maturation of functional synapses between nerve cells, is an essential step in the development of neuronal networks in the brain. It is thought to be triggered by members of the neuroligin family of postsynaptic cell adhesion proteins, which may form transsynaptic contacts with presynaptic alpha- and beta-neurexins and have been implicated in the etiology of autism. We show that deletion mutant mice lacking neuroligin expression die shortly after birth due to… CONTINUE READING
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