Neuroligins Determine Synapse Maturation and Function


Synaptogenesis, the generation and maturation of functional synapses between nerve cells, is an essential step in the development of neuronal networks in the brain. It is thought to be triggered by members of the neuroligin family of postsynaptic cell adhesion proteins, which may form transsynaptic contacts with presynaptic alpha- and beta-neurexins and have been implicated in the etiology of autism. We show that deletion mutant mice lacking neuroligin expression die shortly after birth due to respiratory failure. This respiratory failure is a consequence of reduced GABAergic/glycinergic and glutamatergic synaptic transmission and network activity in brainstem centers that control respiration. However, the density of synaptic contacts is not altered in neuroligin-deficient brains and cultured neurons. Our data show that neuroligins are required for proper synapse maturation and brain function, but not for the initial formation of synaptic contacts.

DOI: 10.1016/j.neuron.2006.09.003

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@article{Varoqueaux2006NeuroliginsDS, title={Neuroligins Determine Synapse Maturation and Function}, author={Frederique Varoqueaux and Gayane Aramuni and Randi L. Rawson and Ralf Mohrmann and Markus Missler and Kurt Gottmann and Weiqi Zhang and Thomas Christian S{\"{u}dhof and Nils Brose}, journal={Neuron}, year={2006}, volume={51}, pages={741-754} }