Neuroligin 2 is required for synapse development and function at the Drosophila neuromuscular junction.

@article{Sun2011Neuroligin2I,
  title={Neuroligin 2 is required for synapse development and function at the Drosophila neuromuscular junction.},
  author={Mingkuan Sun and Guanglin Xing and Liudi Yuan and Guangming Gan and David K. Knight and Sheila Irene With and Cui He and Junhai Han and Xiankun Zeng and Ming Fang and Gabrielle L Boulianne and Wei Xie},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2011},
  volume={31 2},
  pages={687-99}
}
Neuroligins belong to a highly conserved family of cell adhesion molecules that have been implicated in synapse formation and function. However, the precise in vivo roles of Neuroligins remain unclear. In the present study, we have analyzed the function of Drosophila neuroligin 2 (dnl2) in synaptic development and function. We show that dnl2 is strongly expressed in the embryonic and larval CNS and at the larval neuromuscular junction (NMJ). dnl2 null mutants are viable but display numerous… CONTINUE READING

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