Neuroligin 2 controls the maturation of GABAergic synapses and information processing in the retina.

@article{Hoon2009Neuroligin2C,
  title={Neuroligin 2 controls the maturation of GABAergic synapses and information processing in the retina.},
  author={Mrinalini Hoon and Gabriele Bauer and J. -M. Fritschy and Tobias Moser and Bj{\"o}rn H Falkenburger and Frederique Varoqueaux},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2009},
  volume={29 25},
  pages={8039-50}
}
In the present study, we investigated the role of Neuroligin 2 (NL2) in synaptic transmission and network function using the mouse retina as a model circuit. We show that NL2 is preferentially located at GABAergic rather than glycinergic or glutamatergic postsynapses. The absence of NL2 from the retina resulted in a severe reduction of GABA(A) receptor clustering, and in subtle alterations of the retinal circuitry. Light processing was impaired accordingly, and retinal ganglion cells, the… CONTINUE READING
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