Neuroligin-1 links neuronal activity to sleep-wake regulation.

  title={Neuroligin-1 links neuronal activity to sleep-wake regulation.},
  author={Janine El Helou and Erika B{\'e}langer-Nelson and Marl{\`e}ne Freyburger and St{\'e}phane Dorsaz and Thomas Curie and Francesco La Spada and Pierre-Olivier Gaudreault and {\'E}ric Beaumont and Philippe Pouliot and Fr{\'e}d{\'e}ric Lesage and Marcos Gabriel Frank and Paul Franken and Val{\'e}rie Mongrain},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={110 24},
Maintaining wakefulness is associated with a progressive increase in the need for sleep. This phenomenon has been linked to changes in synaptic function. The synaptic adhesion molecule Neuroligin-1 (NLG1) controls the activity and synaptic localization of N-methyl-d-aspartate receptors, which activity is impaired by prolonged wakefulness. We here highlight that this pathway may underlie both the adverse effects of sleep loss on cognition and the subsequent changes in cortical synchrony. We… CONTINUE READING
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