Neuroligin-1 Knockdown Suppresses Seizure Activity by Regulating Neuronal Hyperexcitability

  title={Neuroligin-1 Knockdown Suppresses Seizure Activity by Regulating Neuronal Hyperexcitability},
  author={Min Fang and Jin-Lai Wei and Bo Tang and Jing Liu and Ling Chen and Zhao-Hua Tang and Jing Luo and Guo-Jun Chen and Xue-Feng Wang},
  journal={Molecular Neurobiology},
Abnormally synchronized synaptic transmission in the brain leads to epilepsy. Neuroligin-1 (NL1) is a synaptic cell adhesion molecule localized at excitatory synapses. NL1 modulates synaptic transmission and determines the properties of neuronal networks in the mammalian central nervous system. We showed that the expression of NL1 and its binding partner neurexin-1β was increased in temporal lobe epileptic foci in patients and lithium-pilocarpine-treated epileptic rats. We investigated… CONTINUE READING
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