Neuroleptic interference with the cocaine cue: Internal stimulus control of behavior and psychosis

@article{Colpaert1978NeurolepticIW,
  title={Neuroleptic interference with the cocaine cue: Internal stimulus control of behavior and psychosis},
  author={F. C. Colpaert and Carlos J. E. Niemegeers and Paul A. J. Janssen},
  journal={Psychopharmacology},
  year={1978},
  volume={58},
  pages={247-255}
}
The ability of cocaine to exert internal stimulus control of behavior was investigated by training rats to discriminate 10 mg/kg cocaine from saline in a discrete-trial, two-lever, food-reward procedure. Acquisition of response control by cocaine (1) succeeded in all animals tested, (2) proceeded rapidly, and (3) was associated with a high Commission Error: Omission Error ratio. These findings support the hypothesis that cocaine, a prototype of drugs inducing a psychotic condition in humans… CONTINUE READING
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