Neuroleptic drugs revert the contextual fear conditioning deficit presented by spontaneously hypertensive rats: a potential animal model of emotional context processing in schizophrenia?

@article{Calzavara2009NeurolepticDR,
  title={Neuroleptic drugs revert the contextual fear conditioning deficit presented by spontaneously hypertensive rats: a potential animal model of emotional context processing in schizophrenia?},
  author={M. Calzavara and W. Medrano and R. Levin and S. Kameda and M. Andersen and S. Tufik and R. Silva and R. Frussa-Filho and V. Ab{\'i}lio},
  journal={Schizophrenia bulletin},
  year={2009},
  volume={35 4},
  pages={
          748-59
        }
}
  • M. Calzavara, W. Medrano, +6 authors V. Abílio
  • Published 2009
  • Medicine, Psychology
  • Schizophrenia bulletin
  • Schizophrenia, bipolar disorder, and attention deficit/hyperactivity disorder (ADHD) present abnormalities in emotion processing. A previous study showed that the spontaneously hypertensive rats (SHR), a putative animal model of ADHD, present reduced contextual fear conditioning (CFC). The aim of the present study was to characterize the deficit in CFC presented by SHR. Adult male normotensive Wistar rats and SHR were submitted to the CFC task. Sensitivity of the animals to the shock and the… CONTINUE READING
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