Neuroleptic, antimuscarinic, and antiadrenergic activity of chlorpromazine, thioridazine, and their metabolites

@article{Cohen1979NeurolepticAA,
  title={Neuroleptic, antimuscarinic, and antiadrenergic activity of chlorpromazine, thioridazine, and their metabolites},
  author={B. Cohen and M. Herschel and A. Aoba},
  journal={Psychiatry Research},
  year={1979},
  volume={1},
  pages={199-208}
}
  • B. Cohen, M. Herschel, A. Aoba
  • Published 1979
  • Psychology, Medicine
  • Psychiatry Research
  • Chlorpromazine and thioridazine are widely used antipsychotic agents that are extensively metabolized. Parent compounds and metabolites have diverse pharmacologic activities, and differences in patterns of metabolism may explain differences in therapeutic and side effects from individual to individual. Radioreceptor assays were used to determine the neuroleptic, antimuscarinic, and anti-alpha-noradrenergic potency of chlorpromazine, thioridazine, and their metabolites. The results indicate that… CONTINUE READING
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