Neurokinin3 receptor as a target to predict and improve learning and memory in the aged organism.

@article{Silva2013Neurokinin3RA,
  title={Neurokinin3 receptor as a target to predict and improve learning and memory in the aged organism.},
  author={Maria Ang{\'e}lica de Souza Silva and Bernd Lenz and Andrea Rotter and Teresa Biermann and Oliver Peters and Alfredo Ayala Ram{\'i}rez and Frank Jessen and Wolfgang Maier and Michael Huell and Johannes Schr{\"o}der and Lutz Fr{\"o}lich and Stefan Teipel and Oliver Gruber and Johannes Kornhuber and Joseph P. Huston and Christian M{\"u}ller and Sandra Sch{\"a}ble},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2013},
  volume={110 37},
  pages={
          15097-102
        }
}
Impaired learning and memory performance is often found in aging as an early sign of dementia. It is associated with neuronal loss and reduced functioning of cholinergic networks. Here we present evidence that the neurokinin3 receptors (NK3-R) and their influence on acetylcholine (ACh) release may represent a crucial mechanism that underlies age-related deficits in learning and memory. Repeated pharmacological stimulation of NK3-R in aged rats was found to improve learning in the water maze and… CONTINUE READING
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