Neurokinin A (NK2) receptor revisited with SR 48968, a potent non-peptide antagonist.

@article{Advenier1992NeurokininA,
  title={Neurokinin A (NK2) receptor revisited with SR 48968, a potent non-peptide antagonist.},
  author={Charles Advenier and N E Rouissi and Quoc T Nguyen and Xavier Emonds-Alt and J. C. Breli{\`e}re and Gervais N{\'e}liat and Emmanuel Naline and Domenico Regoli},
  journal={Biochemical and biophysical research communications},
  year={1992},
  volume={184 3},
  pages={1418-24}
}
SR 48968, a new non-peptide antagonist of NK2 receptors, has been tested in a variety of isolated smooth muscle preparations from rats, guinea pigs, rabbits, hamsters and men, in order to assess its selectivity for NK2 receptors as well as its competitivity and specificity. The compound has been found to be inactive as a stimulant or relaxant in all preparations but to exert a potent, competitive antagonism, particularly in tissues obtained from rabbits (pA2 9.8-10.3), guinea pigs (10.5), rats… CONTINUE READING

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