Neurokinin-1 receptor deletion modulates behavioural and neurochemical alterations in an animal model of depression.

@article{Roche2012Neurokinin1RD,
  title={Neurokinin-1 receptor deletion modulates behavioural and neurochemical alterations in an animal model of depression.},
  author={Michelle Roche and Daniel M Kerr and Stephen P. Hunt and John P. J. Kelly},
  journal={Behavioural brain research},
  year={2012},
  volume={228 1},
  pages={91-8}
}
The substance P/NK1 receptor system plays an important role in the regulation of stress and emotional responding and as such had been implicated in the pathophysiology of anxiety and depression. The present study investigated whether alterations in the substance P/NK1 receptor system in brain areas which regulate emotional responding accompany the depressive behavioural phenotype observed in the olfactory bulbectomised (OB) mouse. The effect of NK1 receptor deletion on behavioural responding… CONTINUE READING