Neurokinin-1 receptor antagonists protect mice from CD95- and tumor necrosis factor-alpha-mediated apoptotic liver damage.

@article{Bang2004Neurokinin1RA,
  title={Neurokinin-1 receptor antagonists protect mice from CD95- and tumor necrosis factor-alpha-mediated apoptotic liver damage.},
  author={Renate Bang and Markus Biburger and Winfried L Neuhuber and Gisa Tiegs},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2004},
  volume={308 3},
  pages={1174-80}
}
Previously, we have shown that primary afferent neurons are necessary for disease activity in immune-mediated liver injury in mice. These nerve fibers are detectable by substance P (SP) immunocytochemistry in the portal tract of rodent liver. Antagonists of the neurokinin-1 receptor (NK-1R), which is the prime receptor of SP, prevented liver damage by suppressing the synthesis of proinflammatory cytokines. Here, we investigated the influence of primary afferent nerve fibers, SP, and NK-1… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 16 extracted citations

Overexpression of membrane metalloendopeptidase inhibits substance P stimulation of cholangiocarcinoma growth.

American journal of physiology. Gastrointestinal and liver physiology • 2014
View 2 Excerpts
Highly Influenced

References

Publications referenced by this paper.
Showing 1-10 of 41 references

Contribution of Fas ligand to T cell-mediated hepatic injury in mice.

Gastroenterology • 1997
View 4 Excerpts
Highly Influenced

Molecular mechanisms of hepatic ischemia-reperfusion injury and preconditioning.

American journal of physiology. Gastrointestinal and liver physiology • 2003
View 2 Excerpts

Neurokinin-1 receptor antagonists CP-96,345 and L-733,060 protect mice from cytokine-mediated liver injury.

The Journal of pharmacology and experimental therapeutics • 2003
View 16 Excerpts

Similar Papers

Loading similar papers…