Neurokinin-1 receptor antagonists in the prevention of postoperative nausea and vomiting.

@article{Diemunsch2009Neurokinin1RA,
  title={Neurokinin-1 receptor antagonists in the prevention of postoperative nausea and vomiting.},
  author={Pierre A. Diemunsch and Girish P. Joshi and J. F. Brichant},
  journal={British journal of anaesthesia},
  year={2009},
  volume={103 1},
  pages={7-13}
}
Despite major advances, emesis remains a major problem in the context of cancer chemotherapy and in the postoperative period. A better understanding of the relevant neurocircuitry, especially the central pattern generator responsible for emesis and the central role of substance P, led to the development of a new class of antiemetics: the neurokinin-1 (NK1) receptor antagonists. Aprepitant is the first NK1 receptor antagonist approved for use in postoperative nausea and vomiting, but several… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 34 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 64 references

Aprepitant versus multimodal antiemetic prophylaxis following extended-release epidural morphine

  • T. Yeong-Shiuh
  • ASA Annual Meeting
  • 2008

Similar Papers

Loading similar papers…