Neurokinin 1 receptor antagonism requires norepinephrine to increase serotonin function

@article{Gobbi2007Neurokinin1R,
  title={Neurokinin 1 receptor antagonism requires norepinephrine to increase serotonin function},
  author={G. Gobbi and T. Cassano and F. Radja and M. Morgese and P. Blier},
  journal={European Neuropsychopharmacology},
  year={2007},
  volume={17},
  pages={328-338}
}
The present studies examined the role of norepinephrine (NE) system in mediating the enhancement of 5-HT function produced by neurokinin (NK)1 receptor antagonism. Dorsal raphe 5-HT and locus coeruleus NE neurons were recorded in vivo in mice lacking NK1 receptors in wildtype mice pretreated with the NK1 antagonist RP67580 and its inactive enantiomer RP 68651. RP67580 and RP68651 were also tested on 5-HT neurons of mice lacking the 5-HT(1A) receptor. RP67580 increased the firing rate of 5-HT… Expand
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References

SHOWING 1-10 OF 50 REFERENCES
Modification of serotonin neuron properties in mice lacking 5-HT1A receptors.
Sustained blockade of neurokinin-1 receptors enhances serotonin neurotransmission
Serotonin receptor 1A knockout: an animal model of anxiety-related disorder.
  • S. Ramboz, R. Oosting, +6 authors R. Hen
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 1998
...
1
2
3
4
5
...