Neurokinin 1 receptor antagonism requires norepinephrine to increase serotonin function

@article{Gobbi2007Neurokinin1R,
  title={Neurokinin 1 receptor antagonism requires norepinephrine to increase serotonin function},
  author={Gabriella Gobbi and Tommaso Cassano and Fatiha Radja and Maria Grazia Morgese and Vincenzo Cuomo and Luca Santarelli and Ren{\'e} Hen and Pierre U. Blier},
  journal={European Neuropsychopharmacology},
  year={2007},
  volume={17},
  pages={328-338}
}

Evidence for the differential co-localization of neurokinin-1 receptors with 5-HT receptor subtypes in rat forebrain

TLDR
These experiments demonstrate a high degree of co-localization between NK1Rs and 5-HT1A receptors in cortical and limbic regions of the rat forebrain, and suggest a novel site of interaction betweenNK1R antagonists and the5-HT system.

Neurokinin1 Antagonists Potentiate Antidepressant Properties of Serotonin Reuptake Inhibitors, Yet Blunt Their Anxiogenic Actions: A Neurochemical, Electrophysiological, and Behavioral Characterization

TLDR
Combined NK1 receptor antagonism/5-HT reuptake inhibition may offer advantages in the management of depressed and anxious states: antidepressant properties are reinforced, whereas anxiogenic effects are attenuated.

Sustained Impairment of α2A-Adrenergic Autoreceptor Signaling Mediates Neurochemical and Behavioral Sensitization to Amphetamine

Peripheral CB1 receptor blockade acts as a memory enhancer through an adrenergic-dependent mechanism

TLDR
A novel peripheral mechanism relevant for the modulation of the formation of persistent non-emotional memory is disclosed, and it is disclosed that intra-hippocampal β-adrenergic blockade prevented AM6545 mnemonic effects.

Mutual independence of 5-HT2 and α1 noradrenergic receptors in mediating deficits in sensorimotor gating

TLDR
5-HT2 receptors and α1 and β NE receptors may act through independent mechanisms to modulate sensorimotor gating and locomotor activity and modify PPI.

Enhancement of the function of rat serotonin and norepinephrine neurons by sustained vagus nerve stimulation.

TLDR
Vagus nerve stimulation initially increases the firing activity and pattern of NE neurons and subsequently those of 5-HT neurons, presumably as a cascade effect via alpha(1)-postsynaptic adrenoceptors, and may contribute to the effectiveness of VNS in treatment-resistant depression.

Stress-induced reinstatement of alcohol-seeking in rats is selectively suppressed by the neurokinin 1 (NK1) antagonist L822429

TLDR
The results provide support for NK1 antagonism as a promising mechanism for pharmacotherapy of alcoholism, acting through suppression of stress-induced craving and relapse.

NK1 (TACR1) Receptor Gene ‘Knockout’ Mouse Phenotype Predicts Genetic Association with ADHD

TLDR
The proposal that NK1R−/− mice offer a mouse model of ADHD was borne out by human studies, which suggest that DNA sequence changes in and around the TACR1 gene increase susceptibility to this disorder.
...

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TLDR
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