Neurokinin 1 and 2 receptors mediate cholera toxin secretion in rat jejunum.

  title={Neurokinin 1 and 2 receptors mediate cholera toxin secretion in rat jejunum.},
  author={James L. Turvill and Phillip Connor and M. Farthing},
  volume={119 4},
BACKGROUND & AIMS Substance P, a member of the tachykinin family, is a prosecretory neuropeptide distributed widely throughout the enteric nervous system. Implicated in inflammatory states, its role in enterotoxigenic water and electrolyte secretion is unclear. We assessed the effect of substance P antagonists and neurokinin receptor antagonists on cholera toxin-, Escherichia coli heat-labile enterotoxin (LT)-, and heat-stable enterotoxin (STa)-induced water secretion in an in vivo rat jejunal… CONTINUE READING


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