Neuroinvasive West Nile Infection Elicits Elevated and Atypically Polarized T Cell Responses That Promote a Pathogenic Outcome

@inproceedings{James2016NeuroinvasiveWN,
  title={Neuroinvasive West Nile Infection Elicits Elevated and Atypically Polarized T Cell Responses That Promote a Pathogenic Outcome},
  author={Eddie A James and Theresa J. Gates and Rebecca E Lafond and Shinobu Yamamoto and Chester Ni and Duy H. Mai and Vivian H Gersuk and Kimberly O’Brien and Quynh-Anh Nguyen and Brad Zeitner and Marion Christine Lanteri and Phillip J Norris and Damien Chaussabel and Uma Malhotra and William W Kwok and Ted C. Pierson},
  booktitle={PLoS pathogens},
  year={2016}
}
Most West Nile virus (WNV) infections are asymptomatic, but some lead to neuroinvasive disease with symptoms ranging from disorientation to paralysis and death. Evidence from animal models suggests that neuroinvasive infections may arise as a consequence of impaired immune protection. However, other data suggest that neurologic symptoms may arise as a consequence of immune mediated damage. We demonstrate that elevated immune responses are present in neuroinvasive disease by directly… CONTINUE READING
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