Neuroinflammatory TNFα Impairs Memory via Astrocyte Signaling

@article{Habbas2015NeuroinflammatoryTI,
  title={Neuroinflammatory TNFα Impairs Memory via Astrocyte Signaling},
  author={Samia Habbas and Mirko Santello and Denise Becker and Hiltrud Stubbe and Giovanna Zappia and Nicolas Liaudet and Federica R. Klaus and George Kollias and Adriano Fontana and Christopher R. Pryce and Tobias Suter and Andrea Volterra},
  journal={Cell},
  year={2015},
  volume={163},
  pages={1730-1741}
}
The occurrence of cognitive disturbances upon CNS inflammation or infection has been correlated with increased levels of the cytokine tumor necrosis factor-α (TNFα). To date, however, no specific mechanism via which this cytokine could alter cognitive circuits has been demonstrated. Here, we show that local increase of TNFα in the hippocampal dentate gyrus activates astrocyte TNF receptor type 1 (TNFR1), which in turn triggers an astrocyte-neuron signaling cascade that results in persistent… CONTINUE READING

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