Neuroinflammation in schizophrenia especially focused on the role of microglia

  title={Neuroinflammation in schizophrenia especially focused on the role of microglia},
  author={Akira Monji and Takahiro A Kato and Yoshito Mizoguchi and Hideki Horikawa and Shigenobu Kanba},
  journal={Progress in Neuro-Psychopharmacology and Biological Psychiatry},
An accumulating body of evidence point to the significance of neuroinflammation and immunogenetics also in schizophrenia. Recent genome-wide studies in schizophrenia suggest immune involvement in schizophrenia. Microglia are the resident macrophage of the brain and major players in innate immunity in the CNS. They respond rapidly to even minor pathological changes in the brain and may contribute directly to the neuronal degeneration by producing various pro-inflammatory cytokines and free… CONTINUE READING


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