Neuroinflammation in l-DOPA-induced dyskinesia: beyond the immune function

@article{Pisanu2018NeuroinflammationIL,
  title={Neuroinflammation in l-DOPA-induced dyskinesia: beyond the immune function},
  author={Augusta Pisanu and Laura Boi and Giovanna Mulas and Saturnino Spiga and Sandro Fenu and Anna R Carta},
  journal={Journal of Neural Transmission},
  year={2018},
  volume={125},
  pages={1287-1297}
}
Neuroinflammation is a main component of Parkinson’s disease (PD) neuropathology, where unremitting reactive microglia and microglia-secreted soluble molecules such as cytokines, contribute to the neurodegenerative process as part of an aberrant immune reaction. Besides, pro-inflammatory cytokines, predominantly TNF-α, play an important neuromodulatory role in the healthy and diseased brain, being involved in neurotransmitter metabolism, synaptic scaling and brain plasticity. Recent preclinical… CONTINUE READING
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